kologisk blockering av HMGCR med statiner har som bekant visats sänka LDL-kolesterolet med klinisk användning, men eftersom bestämning av dessa gene-.

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is the key regulatory enzyme for cholesterol biosynthesis. The human gene (HMGCR)has been 

Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. Peroxisomal HMGCR might be coded by a second gene, but is not detected because it is more than 35% different from the ER enzyme. This is confuted by the fact that peroxisomal HMGCR is recognized not only in the catalytic domain but also at epitopes in the membrane-spanning region by several of the same antibodies as the ER enzyme. HMGCR: Description: 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] Organism: Homo sapiens: Synonym(s) b7z3y9, ldlcq3, q8n190 However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays. All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation. Gene name. HMGCR : Synonyms.

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3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. HMG Coenzyme A reductase (Hmgcr) encodes the rate-controlling enzyme of the mevalonate pathway that produces isoprenoids. It is required during heart tube formation, molting regulation and primordial germ cell migration. [Date last reviewed: 2019-05-16] HMGCR Gene Record Summary; Interactions; Claims; HMGCR 3156 Druggable Genome. Alternate Names: 3156 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE HMGCR LDLCQ3 142910 5006 2012-09-18 · The gene encoding HMGCR uses alternative, mutually exclusive exon 1 sequences.

stages of tumorigensis, TGFbeta acquires tumor promoting activities We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine,  as SNP 29, is located in the HMG-CoA reductase HMGCR gene.

Summary of HMGCR This gene encodes an enzyme that catalyzes the rate limiting step in cholesterol biosynthesis (R). 0 users want this gene increased, 0 users want it decreased The Function of HMGCR

The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers.

2014-11-24 · Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides. As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression.

Version: 11-September-2012 Alternate Names: HMDH_HUMAN Uniprot Id HMGCR Uniprot Gene Name P04035 Uniprot Accession Gene … Gene; Hmgcr; Hmgcr. Addgene Alerts Receive email alerts when new plasmids with this gene become available.

2021-01-22 A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study - Volume 104 Issue 5 Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio 2011-01-31 2017-11-20 Gene name.
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Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift Human Gene HMGCR (ENST00000287936.9) Description and Page Index Description: Homo sapiens 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), transcript variant 3, … The Hmgcr gene product has a critical developmental function in providing spatial information to guide migrating primordial germ cells. ( Van Doren et al., 1998 ) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w hs )} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. HMGCR Gene Symbol Gene Info: Target Class Enzymes Target Subclass EC:1.1.1.34 Publications: HopkinsGroom: P04035.

Provided by metabolicatlas.org: Pathway / Subsystem Compartments # proteins # metabolites # reactions for this protein; Transport reactions The HMGCR gene encodes HMG-CoA reductase, a protein best known as being the target for drugs designed to reduce cholesterol levels and thereby reduce the risk for heart disease. SNPs in HMGCR can influence how well such drugs work; they include: rs17244841; rs17238540 HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2: Protein Coding: 51: GC01P056645: 6.85: 3: INSIG1: Insulin Induced Gene 1: Protein Coding: 41: GC07P155297: 6.80: 4: PRKAA1: Protein Kinase AMP-Activated Catalytic Subunit Alpha 1: Protein Coding: 49: GC05M040759: 6.78: 5: APOE: Apolipoprotein E 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl coenzyme A reductase; This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis. Activities of 417bp and 317bp HMGCS1 promoter fragments were 2.5 to 4 fold decreased by ACBP. Concordantly, the levels of HMGCS1-mRNA and -protein were diminished to 60% and 70% in ACBP-expressing HeLa cells, respectively.
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7, Application, AssayType, Gene, AAMutation, TargetName, Validated. 8, MUT, ddPCR hg19, chr5, 65, Yes. 597, CNV, HMGCR, HEX, hg19, chr5, 65, Yes.

The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers.